NAVTEQ

2022年6月27日

一項新的研究蘇黎世瑞士聯邦理工學院的研究人員(蘇黎世聯邦理工學院)合作研究所的專家德不熟悉德爾(ICM-CSIC),發表在科學雜誌《自然》報道揭示了一個新的家庭的存在的海洋細菌的遺傳能力,通過基因組的巨大數量的生物合成基因簇(bgc),可能會導致很多生物技術的應用程序。來源:GEBCO, NOAA, CHS,俄勒岡州立大學,主要研究,CSUMB,國家地理,DeLorme NAVTEQ, Esri。一項新的研究蘇黎世瑞士聯邦理工學院的研究人員(蘇黎世聯邦理工學院)合作研究所的專家德不熟悉德爾(ICM-CSIC),發表在科學雜誌《自然》報道揭示了一個新的家庭的存在的海洋細菌的遺傳能力,通過基因組的巨大數量的生物合成基因簇(bgc),可能會導致很多生物技術的應用程序。家庭屬於門Eremiobacterota,直到現在被認為隻存在於陸地環境。然而,根據現在的工作發表,這些細菌中也發現海洋。”除了是一個非常多樣化的細菌集團的一部分從一個生物合成的角度來看,這些細菌是無所不在地和大量分布在整個海洋水體、“Shinichi Sunagawa解釋說,瑞士蘇黎世聯邦理工學院的教授和團隊領導了這項研究。盧卡斯Paoli,瑞士蘇黎世聯邦理工學院的研究人員和研究的第一作者,強調“家庭的一些物種可以代表6%的細菌在海洋的特定部分,相當於幾百萬生物體每升海水”。這是顯示通過分析期間收集的超過1000個水樣塔拉海洋探險。總的來說,該研究小組已經發現了超過7000個家庭的生物合成基因簇-其中大部分是未知的,可以用來合成生化成分和改善生物技術過程,在其他應用程序中。“這些結果強調知識的缺乏我們有微小的海洋生物。 Only in recent years, thanks to several ocean circumnavigation campaigns and the use of new molecular methods, we have begun to know what organisms, what genes, and what biotechnological potential is hidden under the skin of the ocean”, exposes the ICM-CSIC researcher Josep M Gasol, who has participated in the study. Finally, the ICM-CSIC researcher Silvia G Acinas, a member of the team coordinating the Tara Oceans campaign, points out that “thanks to the integration of thousands of microbial genomes from different expeditions, it has been possible to investigate which microorganisms have great genetic potential, which will serve to explore new bioactive molecules”. According to the researcher, “some of them could be used in new therapies, while others could help to improve certain biotechnological processes and, by extension, our life quality in the future”. Microorganisms, a surprise for industry Microbes, particularly bacteria, are metabolically very diverse and are found in abundance in every corner of nature. However, the vast majority have not yet been cultured or studied in the laboratory, leaving their metabolic diversity unknown. In the absence of cultures, scientific teams have resorted to microbiome sequencing, i.e. sequencing all the DNA contained in the microbial communities of these marine samples in order to reconstruct the genomes of these microorganisms through bioinformatics analysis. “This is how we have been able to reconstruct 25,000 genomes of marine microorganisms which, together with another 10,000 genomes that already existed before, make up the largest database of these communities globally”, celebrates the ICM-CSIC researcher Pablo Sánchez. Future research will focus on the distribution and function of marine microorganisms, as they may play a very important role in the evolution and adaptation of the ocean to the changes that the biosphere is undergoing. DOI